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The first symptoms of COPD appear after about 20 pack-years of smoking, and the disease usually becomes clinically significant after 40 pack-years of smoking.
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Coughing up mucus is often the first sign of COPD.
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Medications prescribed for COPD typically fall into these categories: bronchodilators, corticosteroids, antibiotics and others.
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It usually takes many years for the lung damage to start causing symptoms, so COPD is most common in people who are older than 60.
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Inflammation is followed by scarring and remodeling that thickens the walls and also results in narrowing of the airways.
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This small and unobtrusive device remains the most commonly used inhalation device worldwide (), with estimates of annual production in excess of 800 million units ().